Can we understand biology at the atomic level by looking at a cell’s molecular machinery under the electron microscope? Unfortunately, most human macromolecules are just too small to be studied in noisy, low-contrast images. Now, researchers have imported a 1930s breakthrough in light microscopy to electron microscopy: phase contrast. Physicists are using the world’s most intense continuous-wave laser to quantum-manipulate the wave function of the electron beam to convert small phase shifts into visible image contrast. Macromolecules much smaller than ever are now coming into focus.
Our Wonderfest speaker is Dr. Holger Müller, Professor of Physics at UC Berkeley. He leads the Müller Group in using light to trap molecules and to record subtle biological signals. Dr. Müller also helps the Molecular Biophysics division at Lawrence Berkeley National Lab.
HOW: This event is free and unticketed ... and valuable. But what value does it have FOR YOU (and, indirectly, for society)? Accordingly, please use the DONATE button (below) to support Wonderfest in its nonprofit mission to share the scientific outlook.
Wonderfest Science Envoys are early-career researchers with special communication skills and aspirations. Following short talks on provocative modern science topics, these two Science Envoys will answer questions with insight and enthusiasm:
• UC Berkeley seismologist Sarina Patel on Earthquake Science Using Crowdsourced Data from Smartphones — MyShake is a free citizen-science smartphone app which has been downloaded globally 2.5 million times. MyShake delivers earthquake early warnings(!) to users in California, Oregon, and Washington. It also uses the vibration sensor built into all smartphones to record earthquake motion for scientific analysis. How can the gadget in your pocket contribute to earthquake early warning, shake-hazard mapping, and structural-health monitoring?
• Stanford biophysicist Kevin Aris on Genetic Engineering Refined with Single-Molecule Microscopes — CRISPR enzymes allow precise genetic engineering, cleaving DNA molecules to improve the health and function of organisms. However, naturally compact and twisted pieces of DNA, under stress due to mechanical deformation, are tough to cut precisely. Single-molecule microscopy helps us design novel CRISPR enzymes that become highly-accurate molecular scissors — new tools for beneficial gene modification.
WHAT: Ask a Science Envoy: Earthquake Warning & Genetic Engineering
WHO: Sarina Patel & Kevin Aris, Wonderfest Science Envoys
This free, online, science presentation is produced by Wonderfest in partnership with the Berkeley Public Library.
What value do these science insights have for you? Accordingly, please consider making a donation to nonprofit Wonderfest via the Eventbrite box, below. (Note: No "sales" or "tickets" are involved; it's just a thoughtful contribution to help Wonderfest promote science understanding and the scientific outlook.)
Wonderfest Science Envoys are early-career researchers with special communication skills and aspirations. Following short talks on provocative modern science topics, these two Science Envoys will answer questions with insight and enthusiasm:
• UC Berkeley physicist Jeske Dioquino on “Laser Micro-imaging” — With the help of the electron microscope, researchers are taking pictures of some of nature’s smallest biological structures. To improve the contrast in these images, allowing us to study even smaller structures, a high-intensity laser joins the fray.
• Stanford neurobiologist Marc Harrison on “Mental Time Travel” — As we grow older, our ability to mentally time travel via episodic memory begins to change. Recent advances that utilize biomarkers of disease states, in combination with neuroimaging, have opened exciting new doors in the early detection of Alzheimer’s disease.
WHAT: Ask a Science Envoy: Laser Micro-imaging and Mental Time Travel
WHO: Jeske Dioquino (UC Berkeley) & Marc Harrison (Stanford), Wonderfest Science Envoys
This event is FREE. But what value do these science insights have FOR YOU? Accordingly, please use the space below to contribute to nonprofit Wonderfest, and help to promote the scientific outlook broadly — as through our outstanding Science Envoy Program.
